Ivermectin: 0.4 to 0.6 mg/kg – one dose daily for at least 5 days or until symptoms resolve.
If symptoms persist longer than 5 days, consult a healthcare provider. See Table 1 for help with calculating correct dose. Due to a possible interaction between quercetin and ivermectin, these drugs should be staggered throughout the day (see Table 2). For COVID treatment, ivermectin is best taken with a meal or just following a meal, for greater absorption.

Hydroxychloroquine (HCQ): 200 mg twice a day for 5 to 10 days.
Best taken with zinc. HCQ may be taken in place of, or together with, ivermectin. While ivermectin should be avoided in pregnancy, the FDA considers HCQ safe in pregnancy. Given the pathway used by the Omicron variant to gain cell entry, HCQ may be the preferred drug for this variant.

Mouthwash: 3 times a day.
Gargle three times a day (do not swallow) with an antiseptic-antimicrobial mouthwash containing chlorhexidine, cetylpyridinium chloride (e.g., Scope™, Act™, Crest™), a combination of eucalyptus, menthol, and thymol (Listerine™), or 1% povidone-iodine.

Nasal spray with 1% povidone-iodine: 2-3 times a day.
Do not use for more than 5 days in pregnancy. If 1% product is not available, dilute the more widely available 10% solution (see box) and apply 4-5 drops to each nostril every 4 hours.

• Pour 1 ½ tablespoons (25 ml) of 10% povidone-iodine solution into a 250 ml nasal irrigation bottle.
• Fill bottle to top with distilled, sterile, or previously boiled water.
• To use: tilt head back, apply 4-5 drops to each nostril. Keep head tilted for a few minutes, then let drain.

Quercetin (or a mixed flavonoid supplement): 250-500 mg twice a day.
Due to a possible interaction between quercetin and ivermectin, these drugs should not be taken simultaneously (i.e., should be staggered at different times of day.) As supplemental quercetin has poor solubility and low oral absorption, lecithin-based and nanoparticle formulations are preferred.

Nigella sativa: If using seeds, take 80 mg/kg once a day (or 400 to 500 mg of encapsulated oil twice a day).

Honey: 1 g/kg one to two times a day.

Melatonin: 5-10 mg before bedtime (causes drowsiness).
Slow- or extended-release formulations preferred.

Curcumin (turmeric): 500 mg twice a day.
Curcumin has low solubility in water and is poorly absorbed by the body; consequently, it is traditionally taken with full fat milk and black pepper, which enhance its absorption.

Zinc: 75-100 mg daily.
Take with HCQ. Zinc supplements come in various forms (e.g., zinc sulfate, zinc citrate and zinc gluconate).

Aspirin: 325 mg daily (unless contraindicated).

Kefir and/or Bifidobacterium Probiotics.
NOTE: Depending on the brand, these products can be very high in sugar, which promotes inflammation. Look for brands without added sugar or fruit jellies and choose products with more than one strain of lactobacillus and bifidobacteria. Try to choose probiotics that are also gluten-free, casein-free and soy-free.

Vitamin C: 500-1000 mg twice a day.

Home pulse oximeter
Monitoring of oxygen saturation is recommended in symptomatic patients, due to asymptomatic hypoxia. Take multiple readings over the course of the day and regard any downward trend as ominous. Baseline or ambulatory desaturation under 94% should prompt consultation with primary or telehealth provider, or evaluation in an emergency room. (See box for further guidance.)

• Only accept values associated with a strong pulse signal
• Observe readings for 30–60 seconds to identify the most common value
• Warm up extremities prior to taking a measurement
• Use the middle or ring finger
• Remove nail polish from the finger on which measurements are made

Nitazoxanide (NTZ): 500 mg twice a day for 5 days.

Vitamin D3: For patients with acute COVID-19 infection, calcifediol as dosed in table below is suggested.

B complex vitamins.

Fluvoxamine: 25-50 mg twice a day.
Can substitute fluoxetine (Prozac; 20-40 mg daily) if fluvoxamine not available. NOTE: Some individuals who are prescribed fluvoxamine experience acute anxiety, which needs to be carefully monitored for and treated by the prescribing clinician to prevent rare escalation to suicidal or violent behaviour.

N-acetyl cysteine (NAC): 600-1200 mg orally twice a day.

Omega-3 fatty acids: 4 g daily.
Vascepa (Ethyl eicosapentaenoic acid); Lovaza (EPA/DHA); or alternative DHA/EPA. Vascepa and Lovaza tablets must be swallowed and cannot be crushed, dissolved, or chewed.

Hydroxychloroquine (HCQ): 200 mg twice a day or 400 mg daily for 5 days
AND

Ivermectin: 0.4-0.6 mg/kg once daily for 5 days taken with a fatty meal
OR
Alternative to ivermectin: Nitazoxanide (500 mg three times a day for 5 days taken with a fatty meal).

Zinc: 75-100 mg daily for 5 days

Antiseptci/antimicrobial Mouthwash: 3 times a day.

Nasal spray with 1% povidone-iodine, Carrageenan, Nitric Oxide, or nasal irrigations with saline or neutral electrolyzed water: 2-3 times daily

Quercetin: 250-500 mg twice daily

Melatonin: 5-10 mg at night, slow-release formulation preferred

Nigella sativa: If using seeds, take 80 mg/kg once a day (or 400 to 500 mg of encapsulated oil twice a day taken with honey (1 g/kg one to two times a day).

Aspirin: 325 mg daily unless contraindicated

Home pulse oximetry

Apixaban: 5 mg daily for 15 days
OR

Spironolactone: 200 mg once daily for 7 days
avoid in patients with impaired renal function

Prednisolone: 60 mg daily for 5 days

Oral antibiotic:
Doxycycline (100 mg twice daily for 5 days)
Doxycycline may act synergistically with ivermectin and may be the antibiotic of first choice

OR Azithromycin/Z-pack (500 mg day 1, then 250 mg daily for 4 days)

OR Amoxicillin/Clavulanate (Augmentin) (500 mg/125 mg tablet twice daily for 7 days)